Saturday, April 27, 2013

Movie review: 'Poppy Hill' a warm look at Japan's past | The Salt ...

"From Up on Poppy Hill" ? Umi (right, voiced by Sarah Bolger) and Shun (voiced by Anton Yelchin) ride through Yokohama, circa 1963, in this animated tale directed by Goro Miyazaki (son of the legendary Hayao Miyazaki). (Opens April 26) Studio Ghibly/GKIDS

There?s a welcome gentility to "From Up on Poppy Hill," the latest import from Japan?s Studio Ghibli animation house.

In Yokohama in the early 1960s, everyone is eagerly preparing for the 1964 Tokyo Olympics, and that means cleaning out the old and making room for the new. Schoolgirl Umi (voiced by Sarah Bolger) spends her days looking backward, raising semaphore flags to signal her father, a ship captain presumed dead in the Korean War. When not tending to her grandmother?s boarding house, Umi gets involved in the rescue of her school?s soon-to-be-demolished clubhouse, home to chemistry nerds, philosophers and the campus literary weekly ? which is edited by Shun (voiced by Anton Yelchin), with whom Umi shares a mutual attraction.

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?From Up On Poppy Hill?

Opens Friday, April 26, at the Tower Theatre; rated PG for mild thematic elements and some incidental smoking images; 91 minutes.

Director Goro Miyazaki (son of the legendary Hayao Miyazaki, director of "Spirited Away" and "Ponyo") creates a warm nostalgia piece, a look at school days that is humorous and poignant. Those expecting the fantastical surreal animation that is Ghibli?s trademark will be disappointed, but Miyazaki?s graceful images and expressive characters are delightful.

movies@sltrib.com; www.sltrib.com/entertainment


Copyright 2013 The Salt Lake Tribune. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.sltrib.com/sltrib/entertainment2/56204308-223/hill-miyazaki-poppy-umi.html.csp

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Dems, GOP talk up deficit reduction, but don't act

WASHINGTON (AP) ? Liberals' loud objections to White House proposals for slowing the growth of huge social programs make it clear that neither political party puts a high priority on reducing the deficit, despite much talk to the contrary.

For years, House Republicans have adamantly refused to raise income taxes, even though U.S. taxes are historically low, and the Bush-era tax cuts were a major cause of the current deficit.

And now, top Democrats are staunchly opposing changes to Medicare and Social Security benefits, despite studies showing the programs' financial paths are unsustainable.

Unless something gives, it's hard to see what will produce the significant compromises needed to tame the federal debt, which is nearing $17 trillion.

"There's not much of an appetite for deficit reduction," said Bob Bixby of the Concord Coalition, which pushes for "responsible fiscal policy."

There might be a few small steps this year, he said, when the government again needs to raise its borrowing limit. But a "grand bargain" involving significant spending cuts and revenue increases seems unlikely, Bixby said.

He added, "It's a little depressing to hear the reactions to the president's budget, from both sides."

There was nothing surprising about Republican denunciations of Obama's proposed tax increases, which he wants to combine with spending cuts to reduce the deficit.

The newer wrinkle was the left's sharp criticism of his proposals to slow the growth in Medicare and Social Security benefits, provided Republicans agree to new revenues. Obama has offered Republicans such a deal before. But this month's budget proposal gave it a new imprimatur.

The group MoveOn.org said Wednesday that supporters "who are outraged at President Obama's proposal to cut Social Security benefits will protest and deliver petitions" this week.

Sen. Bernie Sanders, a liberal independent from Vermont, is leading a similar petition drive, opposing "any benefit cuts to Social Security, Medicare or Medicaid." The deficit, his letter says, "was primarily caused during the Bush years by two unpaid-for wars, huge tax breaks for the rich and a prescription drug program" for Medicare, funded through borrowing. He suggests that higher taxes on the wealthy are the fairest way to tackle the deficit.

Democrats cite several reasons to raise taxes on high-income households. Obama campaigned for such tax increases in 2008 and 2012 but accomplished them only partially with the "fiscal cliff" resolution of Jan. 1.

Major tax cuts in 2001 and 2003 played big roles in turning a federal budget surplus into soaring deficits, according to research by the Congressional Budget Office and others. And by many measures, the U.S. tax burden in near historic lows.

Households earning roughly the national median income paid, on average, 11.1 percent of their income in total federal taxes in 2009, the most recent year for such data. That's the lowest level in more than 30 years, the CBO says.

Nonetheless, House Republicans have placed their highest priority on refusing to raise income tax rates, effectively ranking it above all other goals.

"The president got his tax hikes on Jan. 1," House Speaker John Boehner, R-Ohio, is fond of saying. It's a reference to the $620 billion in new revenues, over 10 years, that Republicans were unable to stop because of the "fiscal cliff" law, resolved on New Year's Day.

If it's easy to make a case for higher revenues, the same is true for slowing the growth of Social Security and Medicare benefits. For decades, studies have warned of approaching trouble in these popular but costly programs, as health care costs rise and baby boomers begin to retire.

"Both Medicare and Social Security cannot sustain projected long-run program costs under currently scheduled financing, and legislative modifications are necessary to avoid disruptive consequences for beneficiaries and taxpayers," the Social Security Administration says, summarizing findings by the two programs' trustees.

"The early detection light has been going on for a while, and there has been a failure to act," Social Security trustee Charles P. Blahous recently told a House panel. If lawmakers are to preserve the programs for future retirees, he said, they will have to accept much more "political pain" than officials endured during a 1983 overhaul that included "several extremely controversial measures."

Obama has proposed an often-discussed step, which deals with government accounting in general, not just entitlement programs. If Congress agrees to higher tax revenues, the president said, he would back a slower growth calculation for cost-of-living increases for Social Security benefits, plus higher Medicare premiums for higher-income seniors.

Interest groups have criticized both ideas. AARP calls the slower cost-of-living formula a "harmful change," and urges seniors to oppose it.

American voters can largely blame themselves when Congress is more talk than action on deficit reduction. Americans routinely say they want a smaller federal debt, but not at the cost of programs they hold dear ? including Social Security and Medicare.

A CBS News poll in March found that most Americans want to cut spending and raise taxes to reduce the deficit. But 4 in 5 oppose cuts to Social Security or Medicare. And two-thirds are unwilling to have their own taxes raised in the name of deficit reduction.

When Pew Research asked which was more important ? reducing the national debt or keeping Social Security and Medicare benefits as they are now ? the public sided with safeguarding the benefits programs, 53 percent to 36 percent.

The deficit-spending partisanship continued Wednesday. On a party-line vote, House Ways and Means Committee Republicans passed a bill to protect Social Security recipients and investors in Treasury bonds if the government hits its borrowing limit and can't pay all its bills later this year. Democrats say if the federal government starts reneging on any obligations ? even if it pays bondholders ? financial markets will lose faith and the economy will tank.

Some Democrats fear a lose-lose situation if they support Obama's proposals. First, they could be attacked from the left for tweaking the programs that many Democrats see as their party's greatest legacy. And second, Republicans might accuse them of "raiding Medicare" in next year's congressional elections. That battle cry proved effective in 2010 after Obama's health care overhaul bill was passed.

Democrats call such tactics shamelessly hypocritical. Republicans, they note, have long called for reining in entitlement spending.

Boehner rebuked a top GOP campaign figure for hinting at a renewal of the "raiding Medicare" attacks. But Reince Priebus, the national Republican Party chairman, seemed eager to revive the question of whether Democratic trims to Medicare's costs amount to an unfair cut in benefits.

Source: http://news.yahoo.com/dems-gop-talk-deficit-reduction-dont-act-070757688--finance.html

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Friday, April 26, 2013

Firefly protein lights up degenerating muscles, aiding muscular-dystrophy research

Firefly protein lights up degenerating muscles, aiding muscular-dystrophy research

Thursday, April 25, 2013

Stanford University School of Medicine scientists have created a mouse model of muscular dystrophy in which degenerating muscle tissue gives off visible light.

The observed luminescence occurs only in damaged muscle tissue and in direct proportion to cumulative damage sustained in that tissue, permitting precise monitoring of the disease's progress in the mice, the researchers say.

While this technique cannot be used in humans, it paves the way to quicker, cheaper and more accurate assessment of the efficacy of therapeutic drugs. The new mouse strain is already being employed to test stem cell and gene therapy approaches for muscular dystrophies, as well as drug candidates now in clinical trials, said Thomas Rando, MD, PhD, professor of neurology and neurological sciences and director of Stanford's Glenn Laboratories for the Biology of Aging.

Rando is the senior author of a study, to be published online April 24 in the Journal of Clinical Investigation, describing his lab's creation of the experimental mouse strain in which an inserted gene coding for luciferase, the protein that causes fireflies' tails to glow, is activated only in an important class of rare stem cells that, collectively, serve as a reserve army of potential new muscle tissue. Under normal circumstances, these muscle stem cells, or "satellite cells," sit quietly adjacent to muscle fibers. But muscular injury or degeneration prompts satellite cells to start dividing and then to integrate themselves into damaged fibers, repairing the muscle tissue.

Muscular dystrophy is a genetically transmitted, progressive condition whose hallmark is the degeneration of muscle tissue. There are many different forms, whose severity, time of onset and preference for one set of muscles versus another depends on which gene is defective. But as a general rule, the disease begins to develop well before symptoms show up.

As the muscle fibers of someone with muscular dystrophy die off, nearby satellite cells ? which are normally dormant in the tissue ? begin replicating in an attempt to replace the lost muscle tissue. "But in the end, satellite cells' attempt to restore tissue is overwhelmed," said Rando, who is the founding director of Stanford's Muscular Dystrophy Association Clinic.

No truly effective treatments for muscular dystrophy exist. "Drug therapies now available for muscular dystrophy can reduce symptoms a bit, but do nothing to prevent or slow disease progression," said Rando. Testing a drug's ability to slow or arrest muscular dystrophy in one of the existing mouse models means sacrificing a few of them every couple of weeks and conducting labor-intensive, time-consuming microscopic and biochemical examinations of muscle-tissue samples taken from them, he said.

So Rando decided to design a better mouse. Dozens of mouse models of different varieties of muscular dystrophy, designed to best reflect different forms of the disease, already exist. Rando's team chose to start with a strain whose human analog is called limb-girdle muscular dystrophy. This steadily progressive form of the disease, whose clinical manifestations typically are most pronounced in limb muscles close to the torso (the thigh versus calf, or upper arm versus forearm), begins during the second or third decade of life, after the muscle-building burst of childhood is largely complete.

From that "starter" mouse strain, Rando's team developed another strain of mice that were prone to the same disease process but whose muscle cells contained the luciferase gene. When these mice are 2 months old, Rando and his associates use a sophisticated laboratory technique to activate the luciferase gene in the mice's satellite cells.

Once a luciferase gene is activated in a satellite cell, it stays "on" permanently in that cell and in all of its progeny, including mature muscle cells, causing them to glow whenever the mice are given a compound that gives off light in the presence of luciferase. So, as the muscular dystrophy progressed in the new mouse strain, the damage it inflicted on muscle fibers and the ensuing recruitment of neighboring satellite cells resulted in the affected muscle tissue's being increasingly luminescent. This luminescence, which could be observed through the mice's skin, was strong enough to be monitored and attributed to a precise anatomical location by a highly sensitive camera.

Invasive microscopic and biochemical methods are first able to detect disease symptoms in mice with the limb-girdle-analog strain when they are about 6 months old. In contrast, using this new method, the Stanford team could literally "see" the first signs of the disease's manifestation as early as 3 months.

Rando and his colleagues confirmed the validity of their luminescence assay with parallel examinations of the mice by standard microscopy and biochemical analysis. They also confirmed, in potentially luminescent but otherwise normal mice not suffering from progressive muscle deterioration, that healthy muscle tissue is ordinarily quiescent. In these mice, the Stanford scientists observed negligible luminescent output reflecting the less than 1 percent of all cells in muscle tissue that are satellite cells.

"In these luminescent mice, we could pick up the disease's pathological changes well before they could be seen otherwise," said Rando. "The readout was so sensitive we could observe those changes within a two-week period. Not only that, but we got our measurements instantaneously, without killing the mice."

The new assay's speed, accuracy and relative noninvasiveness will advance the pace of preclinical work, Rando said. "A lot of head-to-head comparisons of muscular-dystrophy therapies, including drugs already in clinical trials as well as stem cell therapies and gene therapies on the near horizon, can now be made that couldn't have been tried before, because they would have been too expensive and time-consuming to make them worth the effort."

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Stanford University Medical Center: http://med-www.stanford.edu/MedCenter/MedSchool

Thanks to Stanford University Medical Center for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127895/Firefly_protein_lights_up_degenerating_muscles__aiding_muscular_dystrophy_research

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Wall Street dips after GDP data; Chevron lifts Dow

By Ryan Vlastelica

NEW YORK (Reuters) - U.S. stocks mostly slipped on Friday as the latest round of economic data indicated that growth fell short of expectations in the latest quarter.

Amazon.com Inc tumbled after results, pressuring both the S&P 500 and Nasdaq, though gains at Hewlett-Packard Co and Chevron Corp kept the Dow in modestly positive territory. Despite the day's decline, major indexes were on track for a week of solid gains.

Gross domestic product expanded at a 2.5 percent rate in the first quarter, below estimates for growth of 3 percent but above the 0.4 percent rate in the fourth quarter of 2012.

The data could raise doubts about the ability of the economy to absorb government spending cuts and higher taxes, and may fuel speculation on the possibility of more Federal Reserve measures to boost growth, or at least keep its current stimulus plans in place.

"The moderate move to the downside isn't out of line with the GDP data as light as it was," said Steve Sosnick, equity-risk manager at Timber Hill/Interactive Brokers Group in Greenwich, Connecticut. "It wasn't so great, but not bad enough to derail the freight train the market has been on."

The S&P is 1.7 percent higher on the week while the Dow is up 1.2 percent and the Nasdaq is up 2.3 percent.

The Thomson Reuters/University of Michigan's final reading on the overall index on consumer sentiment fell to 76.4 from 78.6 in March, although it topped economists' expectations for 73.2 and improved upon the preliminary April reading of 72.3.

Amazon shed 7.1 percent to $255.25 and was the biggest drag on both the S&P and Nasdaq 100 <.ndx> after revenue growth slowed in the first quarter as the world's largest Internet retailer struggled overseas, even as margins jumped on lower shipping expenses.

Chevron rose 1.1 percent to $119.78 after the energy giant posted earnings that beat expectations, helped by foreign currency gains.

"In general, earnings haven't been blockbusters, but the fact that we've had a sharp rally through the season tells you the market is relatively sanguine about what has come out," Sosnick said.

The Dow Jones industrial average <.dji> was up 15.39 points, or 0.10 percent, at 14,716.19. The Standard & Poor's 500 Index <.spx> was down 3.70 points, or 0.23 percent, at 1,581.46. The Nasdaq Composite Index <.ixic> was down 13.35 points, or 0.41 percent, at 3,276.64.

Hewlett-Packard gained 3.2 percent to $20.21, helping to keep the Dow in the green.

Shares of Starbucks Corp , the world's biggest coffee chain, slipped 1 percent to $59.85 after it reported a quarterly profit that matched Wall Street estimates, although revenue was slightly below expectations.

The PHLX housing sector index <.hgx> gained 1.2 percent and was on track for its sixth consecutive advance, getting a lift from D.R. Horton Inc and Weyerhaeuser Co after the No. 1 U.S. homebuilder and forest products company reported earnings.

D.R. Horton shares jumped 7.3 percent to $26.31 though Weyerhaeuser slipped 0.8 percent to $31.12.

With 51 percent of the S&P having reported, 69 percent have beaten earnings expectations, above the 63 percent average since 1994 and slightly over the 67 percent beat rate over the past four quarters.

However, revenue has been lackluster, with only 42 percent topping analyst forecasts, well below the 62 percent average since 2002 and the 52 percent beat rate for the last four quarters.

Analysts now see earnings growth of 3.6 percent this quarter, up from expectations of 1.5 percent at the start of the month.

(Editing by James Dalgleish)

Source: http://news.yahoo.com/wall-st-opens-lower-gdp-data-133821627.html

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Parse Isn't An OS, But It Is Facebook's Answer To Android And iOS

Parse On Android and iOSFacebook doesn't own a mobile operating system, and that's a problem. Developers don't need Facebook to build apps, and it doesn't get a 30% cut of payments. But today Facebook acquired Parse, and while it's not an OS, it's the next best thing. The mobile-backend-as-a-service could keep Facebook top-of-mind for developers when they pick an identity provider, integrate sharing, and buy ads.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/bL2O7_bBFZc/

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Cash-Strapped Mark Sanford Campaign Brings Cardboard Pelosi Out on the Trail

Exactly one week after GOP leaders pulled funding from the Congressional candidate Mark Sanford, the South Carolina Republican appeared at a bizarre campaign event in Charleston Wednesday morning, during which Sanford "debated" a full-color cardboard poster of House Minority Leader Nancy Pelosi, held aloft by one of his campaign staffers. Local reporters captured the scene from multiple angles as Sanford held forth on a sidewalk in front of the?Medical University of South Carolina:

Mark Sanford and Nancy Pelosi cutout as he tries to call out E Colbert Busch twitter.com/skropf47/statu?

? schuyler kropf (@skropf47) April 24, 2013

Anyone else thinking Clint's chair? MT @stefaniebainum Mark Sanford "Debating" Nancy Pelosi on Ashley Ave. by MUSC twitter.com/stefaniebainum?

? Andy Shain (@AndyShain) April 24, 2013

We compiled this GIF from photos taken by reporter Stefanie Bainum of ABC News 4:

RELATED: Mark Sanford Is One Step Closer to Redemption

RELATED: Who Is Stephen Colbert's Sister? (Aside from Being Stephen Colbert's Sister)

Sanford even bragged about the event on his Twitter feed:

Since my opponent won't debate, we decided to "debate" her biggest benefactor, Nancy Pelosi: marksanford.com/2013/04/govern? twitter.com/MarkSanford/st?

? Mark Sanford (@MarkSanford) April 24, 2013

Sanford's website goes on to explain that he staged the event to protest opponent Elizabeth Colbert Busch's decision to publicly debate Sanford only once, and chose to feature Nancy Pelosi because Busch, a Democrat and sister of comedian Stephen Colbert, has supported the Democratic leader's policy initiatives. (Sanford's campaign even cut an ad describing Colbert Busch as "PELOSI'S VOICE.")

RELATED: The Appalachian Trail Ad Democrats Were Waiting to Air

In response, Busch's campaign flayed Sanford: "While Mark Sanford continues his desperate campaign to deceive voters, Elizabeth Colbert Busch is spending her time with real people who support her campaign ... She doesn't have to resort to phony cardboard cutouts to talk with the people of South Carolina."

RELATED: Mark Sanford's Bare-All Apology Tour Isn't Working

Sanford's strange appearance comes a week after the National Republican Congressional Committee decided to pull funding from Sanford's campaign after the candidate was accused of trespassing on his former wife's home on Sullivan's Island, South Carolina ? to watch the Super Bowl with his son, Sanford insisted several times.

RELATED: Elizabeth Colbert Busch Is One Step Closer to Capitol Hill

And the optics on the imaginary Pelosi are perplexing. Remember?Clint Eastwood and the empty chair? Or?Hillary Clinton and the panda mask? Cardboard at a campaign stop isn't exactly on that level, but, hey, maybe Sanford is getting a little desperate ? he's down some 9 points in the polls less than two weeks ahead of the May 7 special election, and he's still got the Appalachian Trail to contend with... sort of.

Source: http://news.yahoo.com/cash-strapped-mark-sanford-campaign-brings-cardboard-pelosi-171251988.html

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CSN: Red Sox rebound, take series vs. A's

BOSTON -- Jon Lester walked six. The bullpen gave up two late-innings run to make things closer than they should have been. And the Red Sox had the bases loaded with no outs in the fifth inning?and failed to add to their lead.

In the end, however, it didn't matter, as the Red Sox rebounded from their worst loss of the season with a 6-5 victory over the Oakland A's Wednesday, giving them five series wins in their first seven series of the year.

Lester spotted the A's a 3-0 lead in the fourth on a three-run?homer by Chris Young, but pitched into the sixth without allowing?another run.

In the meantime, the Red Sox offense got untracked with three runs of their own in the bottom of the fifth -- two on a triple into the right-field corner by the slumping Stephen Drew -- then added three more in the fifth on run-scoring hits from Shane Victorino,?David Ortiz and Jonny Gomes.

Junichi Tazawa gave up a run in the seventh and Koji Uehara?allowed a mammoth solo homer to Young in the eighth, but Andrew Bailey nailed down his fifth save in the last week and third on this homestand.

STAR OF THE GAME: David Ortiz
Ortiz had two more hits -- a double high off the Wall that nearly went out and a run-scoring singles -- as he continues to pound the ball in his first week back in the lineup. In four games since being activated, Ortiz is 8-for-16 (.500) with with three doubles and three RBI.

HONORABLE MENTION: Jon Lester
The six walks weren't anything to brag about and Lester nearly let his emotions get the best of him, showing frustration with the?umpiring crew. But he managed to get into the sixth inning, was scored upon in just one inning and improved to 4-0.

GOAT OF THE GAME: Brett Anderson
Anderson allowed just one hit over the first three innings, but came apart in the fourth and fifth, allowing six runs in those two frames. He was charged with the loss.

TURNING POINT: With the A's rallying with a run off Junichi Tazawa and a runner on second, Andrew Miller, who has struggled recently, came in and struck out Brandon Moss to quell the threat.

BY THE NUMBERS: Mike Napoli has 26 RBI in the first 21 games, the best start to a season by a Red Sox hitter since Mo Vaughn knocked in 26 runs in the first 26 games of 1995.

QUOTE OF NOTE: "I think he showed a little frustration with the strike zone, but he righted the ship and put up a zero after we scored the three runs to tie it.'' -- John Farrell on Lester.

Source: http://www.csnne.com/blog/red-sox-talk/red-sox-rebound-take-series-6-5-win-over

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